溶菌酶和乳铁蛋白在慢性鼻窦炎钩突粘膜中的表达

目的 了解钩突在局部防御慢性炎症过程中的作用。方法 采用免疫组化ＡＢＣ法，检测溶菌酶（ＬＺ）和乳铁蛋白（ＬＦ）在１７侧健康和７０侧慢性鼻窦炎患者（分为单纯炎症组和合并鼻息肉组）钩突粘膜中的表达情况。结果 ①ＬＺ在单纯炎症组钩突粘膜杯状细胞中表达较健康对照组加强（Ｐ〈０．０５）；ＬＦ在健康和慢性鼻窦炎钩突杯状细胞中常为阴性表达；②ＬＺ在健康和慢性鼻窦炎钩突粘膜腺体的浆液性和粘液性细胞中均有表达；ＬＦ

Lysozyme and lactoferrin in human uncinate process mucosa during chronic sinusitis]

OBJECTIVE: To study the local protective role of lysozyme(LZ) and lactoferrin(LF) in the uncinate process mucosa during chronic sinusitis. METHODS: Expression of LZ and LF was determined in 17 samples from normal subjects and 70 samples from chronic sinusitis patients with ABC immunohistochemical method. According to the presence or absence of nasal polyps, patients were divided into two groups. RESULTS: Serous cells of submucosal glands displayed a strongly positive staining reaction to both LZ and LF in the normal uncinate process mucosa and mucosa from patients with chronic sinusitis. A positive though weak staining for LZ could also be found frequently within mucous cells of submucosal mixed glands and occasionally within goblet cells. In the mucosa from patients without nasal polyps, the staining reaction to LZ appeared to be intensified in goblet cells when compared with normal controls (P < 0.05). In patients with nasal polyps, the staining reaction to LZ appeared to be intensified in submucosal glands when compared with normal controls (P < 0.01) and patients without nasal polyps (P < 0.05). For LF, the staining reaction from patients with nasal polyps was stronger than that in normal controls (P < 0.01). The epithial cells stained negatively for LZ and LF. CONCLUSIONS: It suggests that the observed increase in LZ and LF secreting activity of goblet cells and submucosal mixed glands may play a part role in the defense mechanism of uncinate process mucosa during the course of chronic sinusitis.