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| 坦洛新联合托特罗定治疗逼尿肌不稳定前列腺增生的研究 | |
| 引用本文： | 张琼珍,李云祥,何林. 坦洛新联合托特罗定治疗逼尿肌不稳定前列腺增生的研究[J]. 医学理论与实践, 2011, 24(3): 258-260 |
| 作者姓名： | 张琼珍 李云祥 何林 |
| 作者单位： | 四川省南充市中心医院泌尿外科,637000 |
| 摘 要： | 目的:评价坦洛新联合托特罗定治疗前列腺增生(BPH)并逼尿肌不稳定的有效性及安全性。方法:采用随机分组法将80例患者随机分为2组各40例,联合用药组口服坦洛新0.2mg/次(1次/d)+托特罗定2mg/次(2次/d),对照组口服坦洛新0.2mg/次(1次/d),持续4周。比较2组治疗前、后平均IPSS、SSS、QOL评分以及尿流率、残余尿。结果:2组均无因药物副作用中途退出者。治疗前,联合用药组和对照组平均IPSS评分、SSS评分、QOL评分、尿流率以及残余尿量差别无统计学意义(P>0.05);治疗后2组平均IPSS、SSS、QOL评分分别为(11.3±1.9)分、(5.2±0.7)分(、1.9±0.4)分和(15.1±2.3)分、(9.8±2.4)分、(3.9±1.2)分,差别有统计学意义(P<0.01);平均尿流率和残余尿差别无统计学意义(P>0.05)。结论:坦洛新联合托特罗定可改善BPH逼尿肌不稳定患者的下尿路症状和生活质量。对于轻至中度膀胱出口梗阻(BOO)患者,应用托特罗定较安全。 |
| 关 键 词： | 药物治疗 膀胱出口梗阻 逼尿肌不稳定 |
Tamsulosin Combined with Tolterodined in the Treatment of Bladder Outlet Obstruction with Detrusor Instability |
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| ZHANG Qiongzhen,LI Yunxiang,HE Lin. Tamsulosin Combined with Tolterodined in the Treatment of Bladder Outlet Obstruction with Detrusor Instability[J]. The Journal of Medical Theory and Practice, 2011, 24(3): 258-260 | |
| Authors: | ZHANG Qiongzhen LI Yunxiang HE Lin |
| Affiliation: | ZHANG Qiongzhen,LI Yunxiang,HE Lin.Department of Uropoiesis Surgical.The Central Hospital of Nanchong City,Sichuan Province 637000 |
| Abstract: | Objective:To evaluate the effect and safety of tamsulosin combined with Tolterodine in the treatment of bladder outlet obstruction with detrusor instability.Methods:80 patients of BPH with LUTS were identified urodynamically mild ormoderate BOO with DI.The patients were randomized into 2 groups.The study group was given tamsulos 0.2mg/d plus Tolterodine 5mg twice/d,and the control group was given tamsulosin 0.2mg/d.Reevaluation with IPSS,SSS,QOL,urine flow rate and residual volume were done after 4 weeks.Re... |
| Keywords: | Medicine Bladder outlet obstruction Detrusor instability |
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