|
|||||
|
|
| 红花黄色素对衰老模型小鼠肝线粒体膜磷脂影响的实验研究 | |
| 引用本文： | 欧芹,朴金花,张鹏霞,李晶,张涛,魏晓东,孙佳彬,翟金陵. 红花黄色素对衰老模型小鼠肝线粒体膜磷脂影响的实验研究[J]. 中医药学报, 2004, 32(1): 48-50 |
| 作者姓名： | 欧芹 朴金花 张鹏霞 李晶 张涛 魏晓东 孙佳彬 翟金陵 |
| 作者单位： | 1. 佳木斯大学基础医学院,黑龙江,佳木斯,154007 2. 上海市金山区中心医院,上海,201508 3. 佳木斯大学公共计算机教研部,黑龙江,佳木斯,154007 |
| 基金项目： | 黑龙江省教育厅科学技术研究项目 |
| 摘 要： | 目的:探讨小鼠肝线粒体膜磷脂组成的随龄变化及红花黄色素对其的影响.方法:采用HPLC法测定线粒体膜PC、PE、CL的含量,陈思峰法测定PLA2活性.结果:衰老模型组PC、PE、CL均明显降低;PLA2活性随增龄而升高.SYP可升高衰老模型组PC、PE、CL含量;显著降低衰老模型组PLA2活性.结论:D-半乳糖模型出现拟衰老时线粒体膜磷脂改变特征,SYP可显著改善肝线粒体膜磷脂的组成. |
| 关 键 词： | 红花黄色素 衰老模型 线粒体 磷脂 实验研究 |
| 文章编号： | 1002-2392(2004)01-0048-02 |
Experimental study of safflower yellow pigment on Phospholipicl of hepatocytic mitochondria membrane in senile model mice |
|
| OU Qin,PIAO Jin-hua,ZHANG Peng-xia,et al Author's address:. Experimental study of safflower yellow pigment on Phospholipicl of hepatocytic mitochondria membrane in senile model mice[J]. Acta Chinese Medicine and Pharmacology, 2004, 32(1): 48-50 | |
| Authors: | OU Qin PIAO Jin-hua ZHANG Peng-xia et al Author's address: |
| Affiliation: | OU Qin,PIAO Jin-hua,ZHANG Peng-xia,et al Author's address:Department of basic medical college,Jiamusi University,Jiamusi 154007,China |
| Abstract: | Objective:To investigate the age-related changes of phospholipid contents in hepatocytic mitochondria membrane of mice and the effect of safflower yellow pigment(SYP)on hepatocytic mitochondria.Methods:We tested the levels of hepatocytic mitochondria phosphatidyl chorine(PC),phosphatidyl ethanolamine (PE) and cardiolipin (CL) by high pressure liquid chromatography(HPLC) method;Activities of phospholipase A 2(PLA 2) by Chen Sifeng's method.Results:The levels of PC,PE and CL of senile model group were obviously descended,The Activities of PLA 2 was ascended by ageing in mitochondria( P <0.05);SYP cna enhance the levels of PC,PE and CL in mitochondria( P < 0.01 );But obviously descend the activities of PLA 2 of senile model mice.Conclusion:SYP can obviously improve the phospholipid contents in hepatocytic mitochondria membrane. |
| Keywords: | Safflower yellow pigment Senile model mice Mitochondria Phospholipid |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |