| 可乐定对大鼠烫伤后心脏β—肾上腺素受体—腺苷酸环化酶—环腺苷… |
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| 引用本文： | 何华美,孙继武.可乐定对大鼠烫伤后心脏β—肾上腺素受体—腺苷酸环化酶—环腺苷…[J].中国药理学报,1997,18(2):146-149. |
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| 作者姓名： | 何华美 孙继武 |
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| 作者单位： | 第三军医大学药理教研室 |
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| 摘 要： |
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| 关 键 词： | 可乐定 烧伤 肾上腺素受体 AC cAMP |
Effects of clonidine on myocardial beta-adrenergic receptor-adenyl cyclase-cAMP system after scalds in rats. |
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| H M He,J W Sun,C R Xiao,Y N Song.Effects of clonidine on myocardial beta-adrenergic receptor-adenyl cyclase-cAMP system after scalds in rats.[J].Acta Pharmacologica Sinica,1997,18(2):146-149. |
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| Authors: | H M He J W Sun C R Xiao Y N Song |
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| Institution: | Department of Pharmacology, Third Military Medical College, Chongqing, China. |
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| Abstract: | AIM: To study the role of clonidine (Clo) on the myocardial beta-adrenergic receptor (beta-AR)-adenyl cyclase (AC)-cAMP system after the scalds in rats. METHODS: A 30% skin-full-thickness scald was produced by immersing rats in 95 degrees C water for 9 s. Clo 0.1-3.0 mg.kg-1 was injected i.p. to rats at 30 min before scalds, yohimbine (Yoh) 0.05 mg.kg-1 or prazosin (Pra) 0.03 mg.kg-1 to rats at 30 min before i.p. Clo. beta-AR density and affinity, AC activity, phosphoric diester hydrolases (PDH) activity, and cAMP content were determined with radioreceptor assay, indirect method, enzymeradiochemical assay, and radioimmunoassay, respectively. RESULTS: Clo inhibited the decrease of the myocardial beta-AR density, the attenuation of AC activity, and the reduction of cAMP content at 12 h after the scalds. Yoh partially reversed the effects of Clo on the three parameters. But Pra did not. CONCLUSION: Clo reversed the changes of the myocardial beta-AR-AC-cAMP system resulted from the scalds in rats. |
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