兔蓝斑兴奋引起动脉血压升高

目的：研究电刺激和化学刺激兔蓝斑（ＬＣ）对动脉血压（ＡＰ）和肾交感神经传出活动（ＲＳＡ）的影响。方法：电刺激ＬＣ，ＬＣ微量注射Ｌ－Ｇｌｕ、盐酸吗啡、ＧＡＢＡ、电解毁损ＬＣ，记录ＡＰ和ＲＳＡ。结果：电刺激ＬＣ和ＬＣ注射Ｌ－Ｇｌｕ均引起ＡＰ升高分别为１３．５±０．３ｖｓ１９．５±０．８ｋＰａ和１３．８±０．４ｖｓ１７．５±０．８ｋＰａ）和ＲＳＡ增加。ＬＣ注射吗啡、ＧＡＢＡ对ＡＰ和ＲＳＡ无明显影响。电解

Stimulation of locus coeruleus increases arterial pressure in rabbits.

AIM: To study the effect of electric and chemical stimulation of locus coeruleus (LC) on arterial pressure and renal sympathetic nerve discharge activity (RSA). METHODS: Electric stimulation of LC and microinjection of L-glutamate (L-Glu), morphine, and GABA into the LC of rabbits were made. The LC was destructed electrolytically. Arterial pressure and RSA were recorded. RESULTS: Both electric stimulation (150 microA, 50 Hz) of the LC and microinjection of L-Glu (0.5 mumol) into unilateral LC elicited increases in arterial pressure (13.5 +/- 0.3 vs 19.5 +/- 0.8 kPa, P < 0.01 and 13.8 +/- 0.4 vs 17.5 +/- 0.8 kPa, P < 0.01, respectively) and RSA (by 107 +/- 14%, P < 0.01, and 88 +/- 21%, P < 0.01, respectively). Microinjection of morphine or GABA did not induce any significant changes in the above two parameters. Electrolytic lesion of the LC eliminated the pressor response induced by microinjection of L-Glu. CONCLUSION: Excitation of LC has a pressor effect in rabbits, but LC is not a crucial nucleus in tonic regulation of blood pressure.