| 雌激素诱导小鼠腹腔巨噬细胞凋亡 |
| |
| 引用本文： | 张修武 郭兆贵. 雌激素诱导小鼠腹腔巨噬细胞凋亡[J]. 中国药理学报, 1997, 18(3): 267-270 |
| |
| 作者姓名： | 张修武 郭兆贵 |
| |
| 作者单位： | 湖南医科大学分子药理研究室 |
| |
| 摘 要： | ![]()
|
| 关 键 词： | 雌二醇 细胞凋亡 巨噬细胞 |
Estrogens induce apoptosis in mouse peritoneal macrophages. |
| |
| X W Zhang,X L Niu,Z G Guo. Estrogens induce apoptosis in mouse peritoneal macrophages.[J]. Acta Pharmacologica Sinica, 1997, 18(3): 267-270 |
| |
| Authors: | X W Zhang X L Niu Z G Guo |
| |
| Affiliation: | Laboratory of Molecular Pharmacology, Hunan Medical University, Changsha, China. |
| |
| Abstract: | ![]()
AIM: To study whether estrogen might induce apoptosis in mouse peritoneal macrophages (MPM). METHOD: The MPM were isolated and incubated in culture medium containing 17-beta-estradiol, estrone, or equal volume of 100% ethanol as control. DNA fragmentation was visualized by agarose gel electrophoresis. RESULTS: 17-beta-Estradiol 0.01-1 mumol.L-1 or estrone 10-20 mumol.L-1 elicited typical morphological apoptosis and DNA fragmentation in a concentration-dependent manner in MPM. Staurosporine (Sta) 0.01 mumol.L-1, cycloheximide (Cyc) 1 mg.L-1, and tamoxifen (Tam) 10 mumol.L-1 inhibited the DNA fragmentation induced by 17-beta-estradiol 1 mumol.L-1 or estrone 20 mumol.L-1. CONCLUSION: Estradiol and estrone induced apoptosis in MPM. |
| |
| Keywords: | |
| 本文献已被 维普 等数据库收录！ |
|
