同型半胱氨酸与叶酸、维生素B12及维生素B6的关系

目的　探讨正常人群血同型半胱氨酸 (Hcy)水平分布及Hcy与年龄和性别的关系 ,Hcy水平与叶酸 ,维生素B1 2 及维生素B6之间的关系。方法　应用高效液相色谱 (HPLC)荧光检测法测定6 88例正常人血浆Hcy水平 ,用放射免疫方法测定叶酸及维生素B1 2 水平 ,用 96孔板微生物学法测定血清维生素B6水平。结果　相关分析结果显示 :血浆Hcy水平在正常人中呈非正态分布 ,随年龄增长血浆Hcy水平增加 ,男性比女性高。血浆Hcy水平与维生素B6、维生素B1 2 及叶酸水平呈负相关 (r分别为 - 0 35 4 8,- 0 2 91 6 ,- 0 32 76 ,P值均 <0 0 1 )。高Hcy血症者较非高Hcy血症者其血维生素B6、维生素B1 2 及叶酸水平均明显降低 (P值均 <0 0 1 )。结论　正常人中增高的血浆Hcy浓度与体内的维生素水平低下有关。

The relationships between hyperhomocysteinemia and folic acid,vitamin B12 and vitamin B6

Objective To explore the plasma homocysteine(Hcy)level distribution of normal Chinese population and the relationship between Hcy level and age and sex, and to investigate the association between plasma Hcy and vitamin B 6,vitamin B 12 ,and folic acid. Method Plasma Hcy level of 688 normal people was measured by highperformance liquid chromatography (HPLC), plasma folic acid and vitamin B 12levels were measured by radioimmunoassay, and serum vitamin B 6 was measured by microbial assay. Results Results shew that the distribution of Hcy values in normal subjects was skewed. Hcy level increased with age, and Hcy level in males was higher than in females .The plasma Hcy level correlated negatively with vitamin B 6, vitamin B 12and folic acid levels(r=-0.3548, -0.2916, -0.3276, P<0.01). After adjustment for age and sex, Hcy still correlated negatively with vitamin B 6, vitamin B 12and folic acid (P<0.01).Conclusion Elevated Hcy levels of normal Chinese people was significantly associated with the reduction of vitamins.