妊娠晚期邻苯基苯酚暴露与新生儿体格指标的关系

目的 探讨孕妇妊娠晚期尿中邻苯基苯酚(o-phenylphenol,OPP)水平与新生儿出生体格指标之间联系。方法 选取某县1 100对孕妇-新生儿,采集孕妇分娩前尿样并完成调查问卷,测定尿中OPP浓度,结合新生儿体格指标进行统计分析。结果 孕妇尿中OPP的检出率为100%,中位值为0.35 μg/L,肌酐校正后中位值为0.54 μg/g,暴露水平稍高于国外类似研究报道。广义线性模型分析显示,孕妇尿中OPP肌酐校正浓度对数可能与新生儿出生身长(β=-0.670,P=0.006)及头围(β=-0.505,P=0.001)呈一定的负相关。按新生儿性别分层后,OPP水平可能与男童身长、体重及头围呈一定程度的负相关(P<0.05),而女童则未发现任何相关。结论 该地区孕妇普遍暴露于OPP,其妊娠晚期OPP水平可能与男性新生儿出生身长、体重及头围呈一定负相关。

Association between exposure to o-phenylphenol during pregnancy and offspring size at birth

Objective To assess the association between prenatal exposures to o-phenylphenol (OPP) and newborns' growth. Methods Questionnaires and spot urine samples were collected from 1 100 pregnant women living in a county of Jiangsu Province.Urinary concentrations of OPP were determined.Associations between maternal urinary concentration of OPP and neonate birth outcomes were investigated. Results Urinary OPP was detected in all samples,and the median values were 0.35 μg/L and 0.54 μg/g creatinine.Generalized linear model indicated that log-transformed OPP concentrations with creatinine correction were negatively associated with birth length (β=-0.670,P=0.006) and head circumference at birth (β=-0.505,P=0.001).OPP concentrations were negatively associated with length,weight and head circumference at birth among male newborns (P<0.05). Conclusion The findings suggest that the pregnant women are widely exposed to OPP in the studied county and urinary OPP concentrations of pregnant women are negatively associated with birth size among male newborns.