COX-2在乳腺癌组织中的表达及其临床意义

目的探讨环氧化酶-2(COX-2)在乳腺癌组织中的表达及其临床意义。方法采用Elivision免疫组化技术,检测55例乳腺癌组织标本中COX-2的表达。结果55例乳腺癌组织中COX-2的阳性表达率为50.9%(28/55),其表达与患者的年龄、肿瘤大小、组织分级无关,雌激素受体(ER)、孕激素受体(PR)阴性组的阳性表达率明显高于ER、PR阳性组(P<0.05),其表达与淋巴结转移有关(P<0.01)。结论COX-2在乳腺癌中的表达明显上调,其与乳腺癌的发生、转移及预后均有密切关系,可以作为判断乳腺癌生物学行为的有用指标。

Expression and clinical significance of cyclooxygenase-2 in human breast carcinoma

Objective To study the clinical significance of cyclooxygenase-2(COX-2)expression in breast carcinoma.Methods Fifty-five cases of breast carcinomas was investigated by immunohistochemical(Elivision) assay on the expression of cox-2.Results The positive rate of COX-2 protein was 50.9%(28/55).There was no relationship beween the expression of COX-2 protein and patients' age,tumor size and histological grade,the positive expression of COX-2 protein of the patients with estrogen receptor,progesteron receptor in negative group were significantly higher than those in positive group(P<0.05).The expression of COX-2 was correlated with lymph node metastasis(P<0.01).Conclusion The expressions of COX-2 protein in breast cancer is upregulated.It may play an important role in the development,metastasis and prognosis of breast carcinoma and could be used as an important biologic marker for breast carcinoma.