肾虚骨痛胶囊对去势大鼠股骨无机元素含量和骨灰重量的影响

目的：探讨肾虚骨痛胶囊防治骨质疏松症的机理。方法：本实验以切除卵巢大鼠复制绝经后骨质疏松模型，观察该药对去势大鼠股骨无机元素含量及股骨骨灰重量的影响。实验分为模型组、肾虚骨痛胶囊大、小剂量组、骨疏康阳性对照组以及正常对照组。术后１周开始给药，持续１２０天。结果：３个给药组股骨无机元素Ｃａ、Ｐ、Ｍｇ、Ｚｍ、Ｃｕ、Ｍｎ含量明显高于模型组（Ｐ〈０．０１），两个剂量组间有一定量效关系，与阳性对照组无显性差

Influence of Shenxu Gutong Capsule on Femoral Inorganic Elements Content and Ash Weight in Rats

To explore the mechanism of Shenxu Gutong Capsule (SXGTC) in treating postmenopausal osteo porosis. Methods: Using ovariectomized rats as the model of postmentopausal osteoporosis, the effect of SXGTC on inorganic element content of femur and femoral ash weight of the model rats were surveyed. Animals were divided into model group, SXGTC high dose group, SXGTC low dose group, positive control group (treated with Gushukang) and normal control group. The medication began at one week after operation and lasting for 120 days. Results: The contents of inorganic elements, including Ca, P, Mg, Zn, Cu and Mn in the three medicated groups were higher than those of the model group (P<0.01). The effect of SXGTC was dose dependent. The difference between the SXGTC groups and the active control group was insignificant. The femoral ash weight of the SXGTC high dose group and the active control group was significantly higher than that of the model group (P < 0. 01). Conclusions: SXGTC could antagonize the rat's bony change caused by ovariectomy to increase the inorganic contents in bone, which may, in grneral, lead to a bone-strengthening effect.