糖尿病患者C反应蛋白与尿白蛋白排泄率的关系

目的探讨糖尿病患者C反应蛋白（CRP）与尿白蛋白排泄率（UAER）的关系。方法糖尿病患者100例，根据UAER分成三组：正常蛋白尿组（UAER〈20μg／min）30例，微量蛋白尿组（UAER20～200μg／min）35例，临床蛋白尿组（UAER〉200μg／min）35例，测量患者血脂、体重指数。结果各组阁年龄、性别、BMI、血脂比较无显著性差异，微量蛋白尿组、临床蛋白尿组与正常蛋白尿组病程比较有显著性差异（P〈0．01）。微量蛋白尿组CRP值显著高于正常蛋白尿组（P〈0．05）；临床蛋白尿组CRP值显著高于正常蛋白尿组（P〈0．01）和微量蛋白尿组（P〈0．05）。CPR与UAER呈正相关（r=0．859，P〈0．01）。结论CRP有助于糖尿病肾病的早期诊断。

Relationship between C reactive protein and urinary albumin excretion rate in type 2 diabetes

Objective To investigate the relationship between C reactive protein （CRP） and urinary albumin excretion rate （UAER） in type 2 diabetes. Methods 100 patients type 2 diabetes were divided into 3 groups according to UAER including normal albuminuria （UAER〈20 μg/min） （n= 30）, microalbuminuria（UAER20-200 μg/min） （n=35） and clinical albuminuria （UAER〉200 μg/min） （n=35）. Blood fat and BMI were measured. Results In age, sex, BMI and blood fat, there was no significantly difference between three groups. The course of disease in mieroalbuminuria and clinical albuminuria was significantly longer than that in normal albuminuria（P〈0. 01）. CRP in mieroalbuminuria was higher than that in normal albuminuria（P〈0.05）. CRP in clinical albuminuria was significantly higher than those in normal albuminuria （P〈0.01）and mieroalbuminuria（P〈0. 05）. CRP was correlated with UAER （ r= 0. 859, P〈0. 01）. Conclusion CRP is helpful to the early diagnosis of diabetic nephropathy.