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The spatial organization of olfactory nerve projections
Authors:William B. Stewart  Patricia E. Pedersen
Affiliation:1. Section of Anatomy, Department of Surgery Yale University School of Medicine, New Haven, CT 06510 U.S.A.;2. Section of Neurosurgery, Department of Surgery Yale University School of Medicine, New Haven, CT 06510 U.S.A.;3. Section of Neuroanatomy, Yale University School of Medicine, New Haven, CT 06510 U.S.A.;1. Advanced Facility for Avian Research, London, ON, Canada;2. Neuroscience Graduate Program, University of Western Ontario, London, ON, Canada.;3. Department of Psychology, University of Western Ontario, London, ON, Canada.;4. Department of Biology, University of Western Ontario, London, ON, Canada.;1. Department of Clinical Neurobiology, Medical Faculty of Heidelberg University and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;2. Biotech Research & Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen, Denmark;3. Institute of Neuroscience and Medicine INM-2, Research Centre Jülich GmbH, Leo-Brandt Str., 52425 Jülich, Germany;4. Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH/University Hospital Aachen, Pauwelstr. 30, 52074 Aachen, Germany;5. JARA Translational Brain Medicine, Jülich and Aachen, Germany;1. Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA;2. Medical Scientist Training Program, Duke University School of Medicine, Durham, NC 27710, USA;3. Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA;4. Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA;1. Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan;2. Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan;3. Department of Psychiatry, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan;4. Department of Neuropharmacology, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan;1. Department of Psychology, Hunter College, City University of New York, New York, NY 10065, USA;2. Doctoral Program in Biology, The Graduate Center, City University of New York, New York, NY 10016, USA;3. Neuroscience Institute and Department of Otolaryngology, New York University Langone Medical Center, New York, NY 10016, USA;4. Center for Neural Science, New York University, New York, NY 10003, USA;5. Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel;6. Jerusalem Academy of Music and Dance, Jerusalem 91904, Israel
Abstract:The spatial organization of olfactory nerve projections was examined in the rat. The pathway was traced by orthograde transport of HRP following nasal lavage and by retrograde transport of HRP following injections into the olfactory bulb. The results indicated that there was a broad relationship between the epithelium and the olfactory bulb. Specific regions of the olfactory bulb received input from a large region of the epithelium. However, there was evidence that olfactory nerve terminations were not uniformly dense across their terminal fields. The results suggest that there may be finer sorting of olfactory nerves based on functional specificity.
Keywords:Olfactory bulb   Olfactory epithelium   Horseradish peroxidase
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