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| 血清胱抑素C与糖尿病肾病的关系 | |
| 引用本文： | 徐静,贾爱华,张春虹,王俊宏,丁石梅. 血清胱抑素C与糖尿病肾病的关系[J]. 中华糖尿病杂志, 2009, 17(8): 613-615 |
| 作者姓名： | 徐静 贾爱华 张春虹 王俊宏 丁石梅 |
| 作者单位： | 西安交通大学医学院第二附属医院内分泌科,710004 |
| 摘 要： | 目的探讨血清胱抑素C（CysC）与T2DM的关系及其在糖尿病肾病（DN）发生发展中的意义。方法选择140例T2DM（T2DM组）和30名正常对照（NC组），用放射免疫法测定尿白蛋白；用PENIA法测定血清CysC。结果（1）T2DM组血清CysC浓度明显高于NC组。（2）血清CysC浓度在临床DN组明显高于单纯DM组。（3）血清CysC的AUC^ROC为0．898，与尿白蛋白排泄率的AUC^ROC相当，但明显优于血肌酐。结论血清CysC能够作为检测T2DM患者肾功能损害的指标。 |
| 关 键 词： | 胱抑素C 糖尿病肾病 糖尿病,2型 |
The relationship between serum cystatin C and diabetic nephropathy |
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| Affiliation: | XU Jing, JIA Ai-hua, ZHANG Chun-hong ,et al. (Second Affiliated Hospital of Medical College, Xi＇an Jiaotong University, xi ＇ an 710004, China) |
| Abstract: | Objective To investigate the relationship between serum cystatin C （Cys C） and type 2 diabetes mellitus（T2DM）. Methods The 140 patients diagnosed as T2DM were chosen as case group. The 30 normal individuals were as control group. Urine protein was measured with radioimmunoassay. Cys C was determined by particle-enhanced nephelometry immune assay （PENIA）. Results （1） As compared with control group, the serum cys C increased markedly in case group[-（0.85±0. 62） vs （0.45±0.08）mg/L]. （2） The serum cys C was significantly higher in CDN group than in SDM group [（1.45±0. 92） vs （0. 58±0. 17）mg/L]. （3） The study showed AUC^ROC of cys C was larger than that of Scr, and similar to that of UAER. Conclusions Cys C could be used as sensitive indicator for damage in kidney of type 2 diabetes. |
| Keywords: | Cystatin C Diabetic nephropathy Diabetes,type 2 |
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