替米沙坦联合美托洛尔治疗慢性心力衰竭的疗效观察

目的:观察替米沙坦联合美托洛尔治疗慢性心力衰竭的临床疗效。方法:对我院2008年1月～2010年2月收治的102例慢性心力衰竭患者在强心、利尿、扩血管、抗感染、控制血糖等基础上给予替米沙坦、美托洛尔联合治疗,观察治疗前与治疗后2周心功能,24h动态心电图,心脏B超,测血压、心率,6min步行距离,肝肾功能,电解质,血糖,血尿便常规,心肌酶谱的变化情况。结果:治疗后患者心功能、心率和6min步行距离、左室射血分数(LVEF)、早搏次数均显著减低(P<0.05),且无严重血压下降和心率减低。结论:替米沙坦联合美托洛尔治疗心力衰竭患者疗效好,且不良反应少。

Efficacy Observation of Telmisartan Combined with Metoprolol in the Treatment of Chronic Heart Failure

OBJECTIVE：To observe the efficacy of telmisartan combined with metoprolol in the treatment of chronic heart failure.METHODS：102 patients with chronic heart failure admitted in hospital from Jan.2008 to Feb.2010 were given therapy of cardiotonic,diuresis,vasodilator,anti-infection,blood sugar control.Then patients were additionally treated with telmisartan and metoprolol.The parameters before treatment and after 2 weeks of treatment were determined such as heart function,24 h dynamic electrocardiogram,Bultrasound of heart,blood pressure,heart rate,6 min walking distance,liver and kidney function,electrolytes,blood sugar,urine routine,myocardial enzyme.RESULTS：After treatment,cardiac function,heart rate and 6 min walking distance,left ventricular ejection fraction（LVEF）,the number of premature beats were significantly reduced（P0.05） without serious drop of blood pressure and heart rate.CONCLUSION：Telmisartan combined with metoprolol have sound effect in patients with heart failure with few adverse reactions.