蛇床子素微乳的制备及其透皮能力的研究

目的:制备蛇床子素微乳,并考察其对离体小鼠皮肤的透皮能力。方法:通过测定蛇床子素在不同油相、乳化剂和助乳化剂中的溶解度,结合伪三元相图筛选空白微乳的处方。考察蛇床子素微乳的黏度、电导率和粒径;用药物渗透扩散仪测定蛇床子素微乳的透皮速率。结果:制得的蛇床子素微乳的黏度为8.07mpa·s,电导率为123μS·cm-1,平均粒径为58.0nm。微乳中药物经小鼠皮肤的稳态渗透速率为(33.042±3.1)μg·cm-2·h-1(r=0.9950),是蛇床子素饱和溶液稳态渗透速率的25.5倍。结论:蛇床子素微乳有很强的透皮能力,有望成为蛇床子素的新型透皮给药制剂。

Preparation of Osthole Microemulsion and Its Transdermal Absorption

OBJECTIVE：To prepare osthole microemulsion and investigate its in vitro transdermal absorption ability.METHODS：The blank microemulsion formula was optimized based on the solubility of osthole in different oil phase,emulsifier,co-emulsifier and pseudo-tertiary phase diagrams.The viscosity,conductance and particle size of osthole microemulsion were investigated.The permeation rate of osthole was determined using drug diffusion apparatus.RESULTS：The viscosity,conductance and mean particle size of osthole microemulsion were 8.07 mpa·s,123 μS·cm^-1,58.0 nm,respectively.The steady permeation rate of osthole microemulsions reached（33.042±3.1）μg·cm^-2·h^-1（r=0.995 0）and it was 25.5 times over that of saturated osthole solution.CONCLUSION：The result indicates osthole microemulsion with high permeation rate may be used as new osthole preparation with transdermal delivery.