静脉滴注人免疫球蛋白辅助治疗重症肺炎的疗效观察

目的:观察静脉滴注人免疫球蛋白(IHIG)辅助治疗重症肺炎的疗效。方法:调查入住我院呼吸科的重症肺炎患者共84例,治疗组44例,对照组40例。2组均给予常规吸氧、排痰、抗感染等基础治疗。治疗组患者分为A、B亚组,分别在常规治疗的基部感染评分(CPIS)软件计分,评估患者的感染严重程度并比较用药前、后的分值变化情况与疗效的联系。结果:治疗组的咳嗽咳痰缓解时间、痰菌转阴时间均较对照组缩短,有效率为63.6%,明显好于对照组(32.5%,P<0.05)。治疗A组的X线胸片炎症吸收时间与对照组相比无显著性差异(P>0.05),但治疗B组与对照组比较,差异有统计学意义(P<0.05)。治疗组在应用IHIG后CPIS平均分值较应用前显著降低(P<0.05)。提示用药前、后的CPIS分值变化与疗效联系紧密。结论I:HIG辅助治疗重症肺炎疗效显著,可以预防炎症失控,降低死亡率。

Efficacy Observation of Human Immune Globulin in the Treatment of Severe Pneumonia with Intravenous Infusion

OBJECTIVE：To observe efficacy of human immune globulin（IHIG）via i.v.in the treatment of severe pneumonia.METHODS：84 patients with severe pneumonia in respiratory department were divided into treatment group（44 cases）and control group（40 cases.） Both groups were given conventional therapy,such as inhaling oxygen,clearing phlegm,antiinfection therapy.InTarHreIyat Gi mn2ef0en1tct i～gor5no0 u0sp c omrwgeas.（k CgdiPvI1iS.dde）ds1.ci onrCtiloin ngsi ucsabolfg trswoyuamrpep t Aow amassn dua snsedud b stigorg oneusv paa lnBud.a t ceTl ithnheieyc aslwe eevfreferii ctaayd cdoyif t iiwonenfraeelc ltcyio ognmi.p vaeRrneel daI tiHboIentGs wh1eiep0n 0o f2～ 2sgc0ro0or uep msc.gh a.Cnkliggneis1c alw.d itphu1 l eafmfnoidcacy was compared before and after treatment.RESULTS：Relieve time of cough and expectoration and sputum bacterial conversion time in treatment group were shorter than in control group.The effective rate of treatment group was 63.6%,which was better than that of control group significantly（32.5%,P0.05）.Xray absorption time of inflammation had no significant difference between subgroup A and control group（P0.05）,while there was significant difference between subgroup B and control group（P 0.05.） After treatment the average CPIS score of treatment group was significantly lower than before treatment（P0.05.） The changes of CPIS score closely linked to efficacy before and after treatment.CONCLUSION：Adjunctive therapy of IHIG shows significant efficacy in the treatment of severe pneumonia,prevents inflammation out of control and reduce mortality.