首发以阳性症状为主女性精神分裂症治疗研究

目的:探讨利培酮治疗以阳性症状为主的首发女性精神分裂症患者的事件相关电位(ERP)检查能否为该类患者的诊疗提供客观依据。方法:将44例以阳性症状为主的首发女性精神分裂症患者设为研究组,口服利培酮治疗,观察6周,于治疗前与治疗6周末采用阳性与阴性症状评定量表评定患者的精神症状,同时测定P300和N400的潜伏期和波幅;同期随机抽取40例健康体检女性设为对照组,进行同样的测定,并与研究组测定结果进行对比分析。结果:研究组治疗6周末,阳性与阴性症状量表评分阳性症状分、阴性症状分及总分均较治疗前有显著下降(P<0.05)。治疗前后P300和N400波幅与对照组相比有显著性差异(P<0.05),但治疗6周末研究组P300及N400潜伏期与对照组无显著差异。结论:首发女性精神分裂症患者发作期存在明显ERP活动的病理改变,ERP异常是首发女性精神分裂症较特异的生物学标志。利培酮治疗后,随着临床症状的缓解,ERP得到部分改善。

Case-ControlStudy of ERP Changes after Risperidone Treatment on First-episode Female Schizophrenia Patients with Positive Symptoms

Objective:To explore electrophysiologic examination of cognitive function of the first-episode female schizophrenia using event-related potentials(ERP),whether it can provide objective evidences for diagnosis and therapeutic efficacy of schizophrenia or not.Methods:44 first-episode female schizophrenics(study group)were treated with oral risperidone and observed for 6 weeks. scale for the assessment of positive and negative symptoms(SAPS and SANS)were used to evaluate the psychiatric symptoms and ERP to P300 and N400.40 healthy women were controllers.Results:Compared with pre-treatment,the scores of PANSS,PANSS and total decreased obviously at the end of the 6th week of treatment in the study group(P<0.05).P300 and N400 of amplitude of ERP in study group both pre-and post-treatment were significantly difference than those in control group(P<0.05).But P300 and N400 of latent period at the 6th week were no significantly difference than those in control group(P<0.05).Conclusions:The first-episode female schizophrenia patients exist conspicuous pathological changes on ERP during the period of onset,and ERP improves partiallywith the relief of clinic symptoms after resperidone treatment.ERP can be a biological index for first-episode schizophrenia.