Diagnostic utility of IgG and IgM immunohistochemistry in autoimmune liver disease |
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| Authors: | Roger Klein Moreira Frank Revetta Elizabeth Koehler Mary Kay Washington |
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| Affiliation: | Roger Klein Moreira, Department of Pathology, Columbia University College of Physicians & Surgeons, New York, NY 10038, United StatesElizabeth Koehler, Department of Biostatistics, Vanderbilt University, Nashville, TN 37232, United StatesFrank Revetta, Mary Kay Washington, Department of Pathology, Vanderbilt University, Nashville, TN 37232, United States |
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| Abstract: | AIM:To assess the role of IgM and IgG immunohistochemistry(IHC) in the evaluation of autoimmune liver conditions-autoimmune hepatitis(AIH),primary biliary cirrhosis(PBC),and primary sclerosing cholangitis(PSC).METHODS:Forty one biopsies from untreated patients diagnosed with autoimmune liver disease(AIH,n = 20;PBC,n = 13;PSC,n = 8) and fourteen biopsies of patients with chronic hepatitis C were selected.IgM and IgG-positive plasma cells were counted in each sample.RESULTS:A predominance of IgG-positive plas... |
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| Keywords: | Autoimmune hepatitis Primary sclerosing cholangitis Primary biliary cirrhosis Immunoglobulin Immunohistochemistry |
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