Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity

Authors:	Kitano Masahiro Moriyama Saya Ando Yoshikazu Hikida Masaki Mori Yasuo Kurosaki Tomohiro Okada Takaharu

Affiliation:	Research Unit for Immunodynamics, RIKEN, Research Center for Allergy and Immunology, Yokohama, 230-0045, Japan.

Abstract:	Download : Download high-res image (316KB) Download : Download full-size image Highlights? Antigen-engaged B cells upregulate Bcl6 in the outer follicle to enter GC clusters ? Bcl6 in pre-GC B cells is important for sustaining conjugation with helper T cells ? Bcl6 protein is downmodulated in a number of Tfh cells after their development ? Bcl6-low Tfh cells rapidly terminate proliferation and upregulate IL-7 receptor

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