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Liver sinusoidal endothelial and biliary cell repopulation following irradiation and partial hepatectomy |
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| Authors: | Petra Krause Margret Rave-Frank Hendrik Andreas Wolff Heinz Becker Hans Christiansen Sarah Koenig |
| Affiliation: | Petra Krause, Heinz Becker, Sarah Koenig, Department of General Surgery, University Medical Centre Goettingen, 37099 Goettingen, Germany;Margret Rave-Fränk, Hendrik Andreas Wolff, Hans Christiansen, Department of Radiotherapy, University Medical Centre Goettingen, 37099 Goettingen, Germany |
| Abstract: | AIM: To investigate whether irradiation (IR) and partial hepatectomy (PH) may prepare the host liver for nonparenchymal cell (NPC) transplantation.METHODS: Livers of dipeptidyl peptidase(DPP)-deficient rats were pre-conditioned with external beam IR (25 Gy) delivered to two-thirds of the right liver lobules followed by a one-third PH of the untreated lob-ule. DPP-positive liver cells (NPC preparations enriched for liver sinusoidal endothelial cells (LSECs) and hepatocytes) were transplanted via the spleen i... |
| Keywords: | Cell transplants Dipeptidyl peptidase IV protein Endothelial cells Liver cell transplantation Liver irradiation Liver repopulation |
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