The complement component C4 in black Americans with Type 1 (insulin-dependent) diabetes mellitus |
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| Authors: | B. Budowle J. M. Roseman R. C. P. Go B. O. Barger R. T. Acton |
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| Affiliation: | (1) Department of Microbiology, University of Alabama in Birmingham, Birmingham, Alabama, USA;(2) Department of Epidemiology, University of Alabama in Birmingham, Birmingham, Alabama, USA;(3) Department of Surgery, University of Alabama in Birmingham, Birmingham, Alabama, USA;(4) Diabetes Research and Training Center, University of Alabama in Birmingham, Birmingham, Alabama, USA |
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| Abstract: | ![]()
Summary The complement component C4 variants C4A4, C4B 4 and C4B QO were found to be significantly increased in 64 black patients with Type 1 (insulin-dependent) diabetes compared with 169 black control subjects, yielding relative risks of 3.3, 2.9 and 3.4, respectively. The increased frequencies of C4B 4 and C4B QO in black Type 1 diabetic patients are similar to those found in Caucasoid Type 1 diabetic patients. The data suggest that Type 1 diabetes in black Americans may be partially due to admixture of genes from whites. |
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| Keywords: | Complement component C4 Type 1 diabetes mellitus black Americans |
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