2型糖尿病合并牙周病患者脂联素水平与颈动脉内膜-中膜厚度的关系

目的 探讨2型糖尿病合并牙周病脂联素的变化及与颈动脉内膜-中膜厚度的关系.方法 60例2型糖尿病合并牙周病患者(T2DM+牙周病),50例无牙周病的糖尿病患者(T2DM),测定两组人群空腹血糖(FPG)、空腹胰岛素(FINS)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、脂联素水平,并测量颈动脉内膜-中膜厚度(IMT).同时计算体重指数(BMI)、胰岛素抵抗指数(HOMA-IR),分析2型糖尿病合并牙周病IMT与FPG、FINS、血脂、脂联素的关系.结果 2型糖尿病合并牙周病患者FPG、FINS、TG、IMT、HOMA-IR水平高于无牙周病的糖尿病患者,而HDL-C、脂联素水平低于无牙周病的糖尿病组,差异有统计学意义(P＜ 0.05或P＜0.01).且IMT与年龄、糖尿病病程、FPG、TC、TG、LDL-C、FINS、HOMA-IR、BMI呈正相关(P＜0.05或P＜0.01),与HDL-C、脂联素呈负相关(P＜0.01).结论 2型糖尿病合并牙周病患者血清脂联素水平低于无牙周病的糖尿病组,且低脂联素水平与2型糖尿病合并牙周病患者IMT密切相关.

Relationship between serum adiponection level and the intima-media thickness in type 2 diabetes mellitus with periodontitis

OBJECTIVE To investigate the relationship of serum adiponection level with the intima-media thickness(IMT)in type 2 diabetes mellitus with periodontitis.METHODS The serum samples were taken from 60 cases with T2DM and periodontitis,50 cases with T2DM,fasting plasma glucose(FPG),fasting insulin(FINS),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)and Adiponectin were measured.The intima-media thickness(IMT)was detected.Body mass index(BMI)and homeostasis model assessment of insulin resistance(HOMA-IR)were calculated.RESULTS The patients with type 2 diabetes mellitus and periodontitis had significantly higher levels of FPG,FINS,TG,IMT,and HOMA-IR than type 2 diabetes mellitus.The levels of HDL-C and adiponectin were significantly lower in The patients with type 2 diabetes mellitus and periodontitis.CONCLUSION The level of Adiponectin in type 2 diabetes mellitus with periodontitis were significantly lower than those type 2 diabetes mellitus.Adiponectin may be intimately related to the intima-media thickness.