pNO食管鳞癌nm23、E-cadherin表达与淋巴结微转移关系的研究

目的探讨pN0食管鳞癌nm23、E-cadherin表达与淋巴结微转移的关系。方法采用Evision免疫组化法检测86例pN0食管鳞癌根治术后原发灶nm23、E-cadherin表达,以AE1/AE3为微转移指标检测淋巴结,分析nm23、E-cad-herin表达与淋巴结微转移的关系。结果 86例pN0期食管鳞癌区域淋巴结通过AE1/AE3免疫组化染色,发现31例(36.0%)有淋巴结微转移,并且淋巴结微转移与肿瘤分化程度和浸润深度有密切联系(P﹤0.05);nm23、E-cadherin在pN0期食管鳞癌原发灶表达阳性率分别为65.1%,67.4%,淋巴结微转移与nm23、E-cadherind的表达呈负相关(P﹤0.01)。结论 pN0期食管鳞癌原发灶nm23、E-cadherin表达缺失是淋巴结微转移的高危因素,两者联合检测有望成为评估微转移风险有用指标。

Relationship of nm23 and E-cadherin Expression with Lymph Node Micrometastasis of pN0 Esophageal Squamous Cell Carcinoma

OBJECTIVE To investigate the correlation of non-metastasis 23 (nm23) and epithelial cadherin (E-cadherin) expression with lymph node micrometastasis in pN0 esophageal squamous cell carcinoma. METHODS Immunohistochemistry was used to detect nm23 and E-cadherin in primary cancer tissue and AE1 / AE3 in lymph node. RESULTS Lymph node micrometastasis was found in 31 (36.0%) patients. It was closely correlated to differentiation degree, invasion depth, negative expression of nm23 and E-cadherin (P﹤0.05). CONCLUSION The examination of nm23 and E-cadherin expression in primary tumors may be useful for predicting lymph node micrometastasis.