冠心病患者血浆脑钠肽与心功能相关性的临床观察

目的评价冠心病(CHD)患者血浆脑钠肽(BNP)浓度变化与心功能的相关性。方法用微粒子酶免化学发光法(MEIA)检测86例CHD患者血浆BNP浓度,分析其与NYHA心功能分级之间的相关性,并比较其与并发症之间的关系。结果①血浆BNP浓度与NYHA心功能分级成正相关(P<0.01);②CHD并发症与BNP浓度之间存在相关关系;③血浆BNP浓度对CHD心功Ⅰ级的诊断界值选76pg/Ml,其灵敏度为60%。结论BNP测定可用来判断CHD患者心脏功能状态,尤其是隐匿性心力衰竭(HF)患者。

The relativity clinic observation between plasma brain natriuretic peptide and the heart function in patients with coronary heart disease

Objective Evaluate the coronary heart disease(CHD) sufferer the plasma brain natriuretic peptide(BNP) density variety and it with the relativity of the heart function. Methods Examine 86 CHD with the microparticle enzyme immunoassay(MEIA) sufferer the BNP density, analytical it with relativity between the NYHA heart function ratings,and compare it with the relation between complications. Results (1)The BNP density and NYHA heart function ratingses become just related(P<0.01).(2)Complications of CHD and of the plasma BNP exist the related relation. (3)The BNP density is worth for the 76 pg/ml to be one diagnosis field value of the class of the CHD heart function, its intelligent degree is 60%. Conclusion The plasma BNP level measurement can be used to judge the CHD sufferer the heart function appearance, particularly those concealment mental exertions that has no typical model clinic performance crock up the sufferer.