Effects of human amniotic fluid and membrane in the treatment of Achilles tendon ruptures in locally corticosteroid-induced Achilles tendinosis: An experimental study on rats |
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| Authors: | İbrahim Çoban İsmail Safa Satoğlu Alper Gültekin Burçin Tuna Hasan Tatari Mustafa Fidan |
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| Affiliation: | 1. Dokuz Eylül University, School of Medicine, Department of Orthopaedics and Traumatology, Balçova, ?zmir, Turkey;2. Dokuz Eylül University, School of Medicine, Department of Pathology, Balçova, ?zmir, Turkey;3. Dokuz Eylül University, School of Medicine, Department of Biophysics, Balçova, ?zmir, Turkey;1. Department of Surgery, College of Medicine, Mayo Clinic, Rochester, MN;2. Department of Health Science Research, College of Medicine, Mayo Clinic, Rochester, MN;2. Department of Musculoskeletal Disorders, University of Salerno School of Medicine and Surgery, Salerno, Italy;3. Centre for Sports and Exercise Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Mile End Hospital, London, England;1. Center for Stem Cell and Tissue Engineering, School of Medicine, Zhejiang University, Hangzhou, 310058, China;2. Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine, Hangzhou, 310058, China;3. Department of Sports Medicine, School of Medicine, Zhejiang University, Hangzhou, China;4. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;5. State Key Laboratory for Modi?cation of Chemical Fibers and Polymer Materials, Donghua University, Shanghai, 201620, China;6. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China;7. Department of Biosystems Science & Engineering (D-BSSE), ETH-Zurich, Mattenstrasse 26, Basel, 4058, Switzerland;1. Department of Plastic and Reconstructive Surgery, Shanghai Ninth People''s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering Research, National Tissue Engineering Center of China, Shanghai, PR China;2. College of Textiles, Donghua University, Shanghai, PR China;1. Department of Orthopedic surgery, Jameson Crane Sports Medicine Institute, Ohio State University, 2835 Fred Taylor Drive, Columbus, OH 43202, USA;2. Department of Orthopedic Surgery, Brigham & Women’s Hospital, 75 Francis Street, Boston, MA 02115, USA;3. Department of Orthopedic surgery, Hospital for Special Surgery, Weill-Cornell Medical School, 535 East 70th Street, New York, NY 10021, USA |
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| Abstract: | BackgroundTo determine the effects of human amniotic fluid and membrane in the treatment of Achilles tendon ruptures, 72 tendons of 36 Wistar rats were injected with betamethasone sodium phosphate.MethodsBy the end of fourth week, both tendons were tenotomized and repaired, then the samples were divided into three groups. The first group was left untreated after suturing. Human amniotic fluid was injected to the second and amniotic fluid and membrane were both administered to the third group. Twenty-four tendons were scored at the end of the first week, and 24 at the end of the second week histopathologically, and 24 biomechanically at the end of the third week.ResultsThere was a significant statistical difference only between the histopathological results of Groups 2 and 3 at the first week.ConclusionsHuman amniotic membrane and fluid do not add anything to the healing process of Achilles tendon ruptures in the early phase. |
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