肝素治疗小儿肾病综合征的远期效应

采用无抗凝作用剂量肝素皮下注射治疗小儿肾病综合征２５例，观察了近期疗效与１２～２４月后对皮质激素或环磷酰胺（ＣＴＸ）治疗反应的关系．结果表明，近期对肝素治疗显效但复发以及有效者，今后用激素或ＣＴＸ治疗均可达完全缓解，无效者则效果较差．本文结果表明，肝素治疗的近期疗效可用于预测肾病患儿的远期预后．

Long-term Effect of Heparin on Nephrotic Syndrome in Children

Twenty-five nephrotic children were treated with heparin(100 U/kg,twice per day),and the relationship between shor-term effect of heparin and the response to prednisone or CTX in 12 to 24 months after heparin treatment was studied.The results showed that alI the patients who responded to heparin treatment at first,including relaping patients,responded to prednisone or CTX treatment and got remission finally;but most of the patients unresponsive to heparin did not respond to prednisone or CTX treatment,or even pulse treatment of CTX.It is demonstrated that the long-term prognosis in nephrotic syndrome in children may be predicted from the short-term effect of heparin in them.