Insulin-like growth factor-1 protects ischemic murine myocardium from ischemia/reperfusion associated injury期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Insulin-like growth factor-1 protects ischemic murine myocardium from ischemia/reperfusion associated injury

Authors:	Davani Ehsan Y Brumme Zabrina Singhera Gurpreet K Côté Hélène C F Harrigan P Richard Dorscheid Delbert R

Affiliation:	(1) McDonald Research Laboratories/iCAPTURE Center, Graduate Student, University of British Columbia, St Paul's Hospital, Vancouver, British Columbia, Canada;(2) BC Centre for Excellence in HIV/AIDS, Graduate Student, University of British Columbia, St Paul's Hospital, Vancouver, British Columbia, Canada;(3) McDonald Research Laboratories/iCAPTURE Center, Post-Doctoral Fellow, University of British Columbia, St Paul's Hospital, Vancouver, British Columbia, Canada;(4) BC Centre for Excellence in HIV/AIDS, Post-Doctoral Fellow, University of British Columbia, St Paul's Hospital, Vancouver, British Columbia, Canada;(5) Clinical Assistant, Professor of Medicine, BC Centre for Excellence in HIV/AIDS, University of British Columbia, St Paul's Hospital, Vancouver, British Columbia, Canada;(6) Assistant Professor of Medicine, McDonald Research Laboratories/iCAPTURE Center, University of British Columbia, St Paul's Hospital, Vancouver, British Columbia, Canada;

Abstract:	Introduction Ischemia/reperfusion occurs in myocardial infarction, cardiac dysfunction during sepsis, cardiac transplantation and coronary artery bypass grafting, and results in injury to the myocardium. Although reperfusion injury is related to the nature and duration of ischemia, it is also a separate entity that may jeopardize viable cells and ultimately may impair cardiac performance once ischemia is resolved and the organ heals.

Keywords:	apoptosis mitochondrial DNA myocardium reperfusion injury sepsis
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Introduction