类风湿因子与抗环瓜氨酸肽抗体和抗角蛋白抗体联合检测对类风湿关节炎的诊断价值

目的探讨类风湿因子(RF)、抗环瓜氨酸肽抗体(抗-CCP)及抗角蛋白抗体(AKA)联合检测在诊断类风湿关节炎(RA)中的价值。方法回顾分析186例RA患者及981例未确诊的病例进行3项抗体检测,并进行统计学比较。结果抗-CCP与AKA检测差异有统计学意义,RF、抗-CCP检测和RF、抗-CCP、AKA联合检测阳性率接近,差异无统计学意义。结论抗-CCP与AKA的靶抗原有一定的相关性,但又不能完全重叠,对不同人群,合理地优化组合RF、抗-CCP与AKA,并结合临床可提高对RA的诊断及鉴别诊断,对于RA的早期诊断、病情发展、预后均有重大作用。

Value of joint detection of RF, anti-CCP and AKA in diagnosis of RA

Objective To investigate the value of combined determination of serum rheumatic factor（RF） ,anti- karatin antibody（AKA） and anti-cyclic citrullinated peptide antibody（anti CCP antibody） levels in the diagnosis of rheumatoid arthritis（RA）. Methods The detection results of three items of antibody in 186 patients with RA and 981 undiagnosed patients were retrospectively analyzed for statistical comparison. Results The anti CCP and AKA levels had statistical difference. The joint detection of the two items and three items had the approximate positive rate without statistical difference. Conclusion Target antigens of anti-CCP and AKA have certain correlation,but is una- ble to completely overlap. Rational and optimal combination of RF, anti-CCP and AKA, combined with clinic, can im- prove the diagnosis and differential diagnosis of RA, which has an important role in early diagnosis, condition develop- ment and prognosis of RA.