不孕不育患者血清中抗精子抗体与抗心磷脂抗体的检测价值

目的探讨抗精子抗体(AsAb)、抗心磷脂抗体(ACA)在不孕不育患者中的检测价值。方法采用酶联免疫吸附试验检测878例不孕不育患者及20例健康对照组血清中的AsAb及ACA。结果不孕不育组抗精子总抗体(AsAbT)的总阳性率为21.4%,IgM阳性率为13.5%;健康组AsAbT总阳性率为7.5%,IgM为0%,P<0.01。不孕不育组ACA检测总阳性率为36.6%,其中IgA阳性率为5.1%,IgG阳性率为30.5%,IgM为12.3%;健康组阳性率为5.0%,其中IgG阳性率为5.0%,IgM为2.5%,P<0.05。结论 AsAb、ACA与不孕不育关系密切,其检测有助于免疫性不孕不育的诊断。

Detective value of antisperm antibody and anticardiolipin antibodies in serum of infertility patients

Objective To investigate the detective value of antisperm antibody（AsAb） and anticardiolipin antibody（ACA）in patients with infertility.Methods ELISA assay was used to detect serum AsAb and ACA in 878 cases of infertility patients,and we compared the result of 20 healthy people as health group.Results In infertility group,the total positive rate of the antisperm antibodies（AsAbT） was 21.4%,and positive rate of IgM was 13.5%.The total positive rate of AsAb and IgM in health group were 7.5% and 0（P〈0.01）;The total positive rates of ACA in infertility group was 36.6%,and the positive rates of IgA,IgG anf IgM were 5.1%,30.5%,12.3%;and in healthy group,the positive rates were 5.0%,（IgG 5.0%,IgM 2.5%）（P〈0.05）.Conclusion AsAb and ACA are closely related to infertility.These can be used clinically as a sensitive index for diagnosis.