急性胰腺炎胰腺组织一氧化氮含量变化及意义

目的：探讨急性胰腺炎(AP)时大鼠胰腺组织一氧化氮(NO)含量变化规律及意义。方法：一次性大剂量精氨酸腹腔内注射制成AP模型，并观察6、12、24、48和72h胰腺组织NO含量的变化。结果：随着胰腺炎病变程度的加重，胰腺组织中NO的含量逐渐下降，并在坏死的高峰(48h)达到最低，此后开始缓慢上升。而对照组则无明显变化。结论：胰腺组织中NO含量降低与胰腺炎病变程度的加重呈正相关。

Content changes of nitric oxide in rat model of pancreatitis

Objective:To identify the role of NO changes in L-arginine induced model of acute pancreatitis in rats. Methods: Acute pancreatitis was induced with a single intraperitoneal injection of 500 mg/100 g body weight of L-arginine. The contents of NO were measured at 6 h,12 h,24 h,48 h,72 h after injection. Results: The content changes of NO in the pancreatic tissues of the rats were decreasing with pancreatitis exacerbating and reaching the lowest value in 48 h when the severity of pancreatic necrosis became serious, then began to rise slowly. The controls had not changed markly. Conclusion: The contents of NO decreasing is relative to the severity of pancreatic necrosis.