Caspofungin activity against clinical isolates of fluconazole-resistant Candida |
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| Authors: | Pfaller Michael A Messer Shawn A Boyken Linda Rice Cassie Tendolkar Shailesh Hollis Richard J Diekema Daniel J |
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| Affiliation: | Departments of Pathology, University of Iowa College of Medicine and College of Public Health, Iowa City, Iowa 52242, USA. |
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| Abstract: | ![]()
A total of 7,837 clinical isolates of Candida were tested against fluconazole, and 351 resistant (fluconazole MIC >/=64 micro g/ml) isolates were identified (4% of the total tested). All fluconazole-resistant isolates were inhibited by caspofungin at concentrations that can be exceeded by standard doses (MIC at which 90% of the isolates were inhibited, 1 micro g/ml; 99% of the MICs were
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