中医辨证治疗对减少乙型肝炎病毒YMDD变异的疗效观察

探讨辨证运用柴芍六君汤对减少乙型肝炎病毒YMDD变异的疗效观察。方法将360例慢性乙型肝炎患者分为对照组60例,治疗组300例,分别给予拉米夫定、柴胡六君汤联合拉米夫定治疗18个月,观察患者ALT复常率、HBeAg阴转率、HBeAg血清转换率、HBV-DNA阴转率及治疗1年及1年半的YMDD变异率。结果治疗组较对照组在ALT复常率、HBeAg阴转率及HBeAg血清转换率、治疗18个月时YMDD变异率方面均明显优于对照组(P<0.05或P<0.01)。结论辨证运用柴芍六君汤联合拉米夫定对改善患者肝功能有良好的作用,能提高拉米夫定抑制病毒复制作用,减少病毒YMDD变异。

Observation on Efficacy of Chinese Medical Syndrome Differentiation in Reduction of HBV YMDD Mutation

Objective:To investigate efficacy on reduction of YMDD-HBV mutation by using Chaishao Liujun Tang (Chaishao Liujun Decoction) with syndrome differentiation.Methods:360 chronic HBV patients were randomly divided into control group (60 cases),treated with lamivudine for 18 months,and treatment group (300 cases),treated with Chaishao Liujun Tang (Chaishao Liujun Decoction) together with lamivudine for 18 months.ALT recovery rate,HBeAg negative seroconversion rate,frequency of seroconversion,HBV-DNA negative seroconversion rate and YMDD mutation rates (12 months,18months) were measured before and after treatment.Results:The treatment group was significantly better in the above indices as compared with those of control group (P<0.05 or P<0.01).Conclusion:Applying Chaishao Liujun Tang (Chaishao Liujun Decoction) with syndrome differentiation can achieve good clinical efficacy in improving patients liver functions,strengthening lamivudine's inhibition for virus mutation,and reducing YMDD mutation.