Dopamine reuptake transporter–single‐photon emission computed tomography and transcranial sonography as imaging markers of prediagnostic Parkinson's disease |
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| Authors: | Alastair J. Noyce MRCP PhD John Dickson PhD Richard N. Rees MRCP Jonathan P. Bestwick MSc Ioannis U. Isaias MD PhD Marios Politis MD PhD Gavin Giovannoni FRCP PhD Thomas T. Warner FRCP PhD Andrew J. Lees FRCP MD Anette Schrag FRCP PhD |
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| Affiliation: | 1. Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK;2. Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, UK;3. UCL Division of Medicine, University College London, London, UK;4. Department of Clinical Neurosciences, Royal Free Campus, UCL Institute of Neurology, University College London, London, UK;5. Department of Neurology, University Hospital Würzburg and Julius‐Maximilians‐University, Würzburg, Germany;6. Neurodegeneration Imaging Group, Maurice Wohl Clinical Neuroscience Institute, Kings College London, London, UK;7. Blizard Institute, Barts and the London SMD, Queen Mary University of London, London, UK |
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| Abstract: | Objective: The objective of this study was to examine whether prediagnostic features of Parkinson's disease (PD) were associated with changes in dopamine reuptake transporter–single‐photon emission computed tomography and transcranial sonography. Methods: Prediagnostic features of PD (risk estimates, University of Pennsylvania Smell Identification Test, Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire, and finger‐tapping scores) were assessed in a large cohort of older U.K. residents. A total of 46 participants were included in analyses of prediagnostic features and MDS‐UPDRS scores with the striatal binding ratio on dopamine reuptake transporter–single‐photon emission computed tomography and nigral hyperechogenicity on transcranial sonography. Results: The striatal binding ratio was associated with PD risk estimates (P = .040), University of Pennsylvania Smell Identification Test (P = .002), Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire scores (P = .024), tapping speed (P = .024), and MDS‐UPDRS motor scores (P = .009). Remotely collected assessments explained 26% of variation in the striatal binding ratio. The inclusion of MDS‐UPDRS motor scores did not explain additional variance. The size of the nigral echogenic area on transcranial sonography was associated with risk estimates (P < .001) and MDS‐UPDRS scores (P = .03) only. Conclusions: The dopamine reuptake transporter–single‐photon emission computed tomography results correlated with motor and nonmotor features of prediagnostic PD, supporting its potential use as a marker in the prodromal phase of PD. Transcranial sonography results also correlated with risk scores and motor signs. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. |
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| Keywords: | Parkinson's disease cohort epidemiology risk factors |
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