| β-胡萝卜素对二甲基亚硝胺致大鼠脂质过氧化的影响 |
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| 引用本文： | 陈起萱,梅节.β-胡萝卜素对二甲基亚硝胺致大鼠脂质过氧化的影响[J].卫生研究,1998,27(2):105-108. |
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| 作者姓名： | 陈起萱 梅节 |
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| 作者单位： | 中山医科大学公共卫生学院营卫教研室，中山医科大学医学营养系 |
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| 基金项目： | 广东省1995年医药卫生科学研究基金 |
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| 摘 要： | 探讨了给予二甲基亚硝胺（ＮＤＭＮ），同时补充β－胡萝卜素（β－Ｃ）后，大鼠体内抗氧化酶活性和脂质过氧化物含量的变化。结果显示，一定剂量的ＮＤＭＮ可使大鼠血红细胞、肝肾匀浆ＳＯＤ活性和全血ＧＳＨ－Ｐｘ活性下降（Ｐ＜０．０５），血清和肝ＭＤＡ和血清ＲＯＯＨ产生增多（Ｐ＜０．０５）。添加β－Ｃ（２５ｍｇ／ｋｇ）后，ＳＯＤ和ＧＳＨ－Ｐｘ活性均比单纯ＮＤＭＮ组有明显提高（Ｐ＜０．０５）。ＭＤＡ和ＲＯＯＨ含量明显低于ＮＤＭＮ组（Ｐ＜０．０５）。提示自由基和脂质过氧化反应可能也是ＮＤＭＮ及其它亚硝胺致癌的途径之一；一定剂量的β－Ｃ可对抗ＮＤＭＮ引起的自由基和脂质过氧化。
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| 关 键 词： | β-胡萝卜素 二甲基亚硝胺 自由基 脂质过氧化 大鼠 |
Efficacy of beta-carotene on lipid peroxidation induced by N-nitrosodimethylamine in rats] |
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| Q Chen,S Wang,J Mei,Y Xu.Efficacy of beta-carotene on lipid peroxidation induced by N-nitrosodimethylamine in rats][J].Journal of Hygiene Research,1998,27(2):105-108. |
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| Authors: | Q Chen S Wang J Mei Y Xu |
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| Institution: | School of Public Health, Sun Yat-sen University of Medical Sciences, Guangzhou, China. |
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| Abstract: | The effect of beta-carotene (beta-C) on lipid peroxidation induced by N-nitrosodimethylamine (NDMN) in rats was studied. Thirty clear conventional SD rats were randomly devided into 3 groups and were intragastricly given daily water (10 ml/kg). NDMN (1.75 mg/kg), and NDMN (1.75 mg/kg) plus beta-C (25 mg/kg) respectively. The results showed that: compared with group 1, the activities of SOD and GSH-Px in NDMN group were significantly decreased (P < 0.05), the values of MDA and ROOH increased (P < 0.05). The activities of SOD and GSH-Px in group 3 were significantly higher and the contents of ROOH and MDA were significantly lower than that of NDMN group (P < 0.05). These results suggested that free radicals and lipid peroxidation may be a carcinogenic path for NDMN and other nitrosamines. beta-C had ability to inhibit the lipid peroxidation induced by NDMN. |
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| Keywords: | β carotene NDMN free radicals lipid peroxidation rat |
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