肝癌免疫治疗策略的进展与思考

中国是肝癌大国，全世界每年>50%的新发和死亡病例发生在中国。肝癌的化疗敏感性较低，以抗血管生成为主的靶向治疗是进展期肝癌的主要系统治疗手段，但能达到的有效率和生存延长作用十分有限。近年来，免疫检查点抑制剂在肝癌临床治疗中展现出较好疗效，正在改变肝癌治疗格局，但也面临诸多问题。如程序性死亡配体-1、肿瘤突变负荷、错配修...

Progress and consideration of immunotherapy strategy for hepatocellular carcinoma

China has a large number of hepatocellular carcinoma patients,and more than half of the new cases and deaths of hepatocellular carcinoma in the world occur in China every year.The chemosensitivity of hepatocellular carcinoma is relatively low.Targeted therapy with antiangio-genic drugs are main treatment options for advanced hepatocellular carcinoma,but the effective rate and survival prolonging effect are very limited.Recently immune checkpoint inhibitors have exhibited promising efficacy in hepatocellular carcinoma,which is changing the pattern of hepatocellular carcinoma treatment.However,challenges still exit.Biomarkers commonly used in clinical practice including programmed death ligand-1,tumor mutational burden and mismatch repair proteins have limited clinical value in hepatocellular carcinoma.Compared with other etiology related liver cancer,hepatitis B related hepatocellular carcinoma in China harbors unique gene mutation map,but the individualized treatment strategy based on molecular typing has not yet been established.More effective and diversified systematic treatment methods can promote the comprehensive treatment of hepatocellular carcinoma into a new era,and the relevant diagnosis and treatments need to be further explored and established.Based on relevant literatures and combined with clinical practices,the authors investigate the progress and consideration of immunotherapy strategy for hepatocellular carcinoma.