Disentangling breast cancer patients' perceptions and experiences with regard to endocrine therapy: Nature and relevance for non-adherence |
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| Authors: | Hans Wouters Erica C.G. van Geffen Monique C. Baas-Thijssen Elly M. Krol-Warmerdam Anne M. Stiggelbout Svetlana Belitser Marcel L. Bouvy Liset van Dijk |
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| Affiliation: | 1. Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands;2. NIVEL, Netherlands Institute for Health Services Research, Utrecht, The Netherlands;3. Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands;4. Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands;1. Department of Oncology and Hematology, Research Institute INCLIVA, Hospital Clinico Universitario Valencia (HCUV), Avda Blasco Ibañez 17, 46010 Valencia, Spain;2. Research Institute INCLIVA, University of Valencia, Spain;3. Department of Pathology, Breast Cancer Unit, Research Institute INCLIVA, HCUV, Spain;4. Department of Statistics, University of Valencia, Spain;5. Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center Houston Texas, USA;1. Department of Surgery, Jeroen Bosch Ziekenhuis, P.O. Box 90153, 5200 ME ''s-Hertogenbosch, The Netherlands;2. Department of Radiology, Jeroen Bosch Ziekenhuis, ''s-Hertogenbosch, The Netherlands;3. Department of Pathology, Jeroen Bosch Ziekenhuis, ''s-Hertogenbosch, The Netherlands;4. Department of Oncology, Jeroen Bosch Ziekenhuis, ''s-Hertogenbosch, The Netherlands;1. Division of Gynecological Oncology, Fondazione del Piemonte per l''Oncologia, Turin, Italy;2. Institute for Cancer Research and Treatment (IRCC) of Candiolo, Strada Provinciale 142, Km. 3.95, 10060 Candiolo, Turin, Italy;3. The Clinical Trials Group, Dept. of Surgery, University College of London (UCL), Clerkenwell Bldg, Whittington Campus, London N19 5LW, UK |
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| Abstract: | Background & study aimsAdjuvant endocrine therapy effectively prevents recurrence and progression of estrogen-receptor positive breast cancer. However, studies reveal substantial non-adherence. The objective was therefore to identify the nature of the experiences and beliefs of women treated with endocrine therapy in an attempt to find potential determinants of non-adherence.MethodOnline Focus Groups (OFGs) and individual interviews were conducted with 37 women who were treated with endocrine therapy. Sixty-three statements derived from the OFGs and 11 belief items from the Beliefs about Medicines Questionnaire (BMQ) were used in a Q-sorting task conducted with 14 of the women. The quantitative Q-sorting data were statistically analyzed with Hierarchical Cluster Analysis.ResultsA six cluster solution was revealed that included the clusters ‘information’, ‘efficacy’, ‘tenacity’, ‘coping’, ‘side effects’ and ‘usage’. Women's own experiences and perceptions were not clearly delineated from the beliefs measured with the BMQ. However, women judged their own experiences and perceptions with regard to endocrine therapy as more relevant for adherence than the BMQ beliefs.ConclusionIn order to understand and to improve women's adherence to endocrine therapy, women's own perceptions and experiences about endocrine therapy should be targeted in addition to common beliefs that apply to a wide range of medicines. |
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| Keywords: | Breast neoplasms Antineoplastic agents Adverse effects Antineoplastic agents Therapeutic use Patient-centered care Patient-preference Patient adherence |
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