双侧睾丸生精小管内精原细胞瘤的诊断和治疗(附1例报告及文献复习)

目的:探讨睾丸生精小管内精原细胞瘤的诊断和治疗。方法:应用睾丸组织活检和病理检查的方法诊断1例双侧睾丸生精小管内精原细胞瘤患者,附睾内获取精子行卵细胞胞质内单精子注射(ICSI),受孕成功后再行双侧睾丸局部放射治疗。结果:睾丸活检病理结果为双侧睾丸生精小管内精原细胞瘤,附睾内获取液中可见大量发育正常的精子,行ICSI失败1次,再次行ICSI,已成功受孕,行双侧睾丸局部60Co放射治疗,双侧睾丸未见肿物生长。结论:睾丸生精小管内精原细胞瘤是生殖细胞瘤的一种类型,无临床症状,多在睾丸活检时发现,早期治疗预后较好,临床医师和病理科医师应给予重视。

Diagnosis and Treatment of Bilateral Testicular Intratubular Seminoma:a Case Report and Review of Literature

Objective: To explore the diagnosis and treatment of testicular intratubular seminoma.Methods: One case of testicular intratubular seminoma was diagnosed with testicular biopsy.Epididymal sperm was aspirated and intracytoplasmic sperm injection(ICSI) was performed.And local radiotherapy was conducted on the bilateral testes after fertilization.Results: The result of testicular biopsy revealed bilateral testicular intratubular seminoma.Large numbers of sperms were found in the epididymal aspirate.ICSI did not succeed for the first time.The second ICSI succeded.The local radiotherapy by ~(60)Co had been conducted on the biateral testes,and testicular tumor didn't develop further.Conclusion: Testicular intratubular seminoma is a type of intratubular germ cell neoplasia,with no clinical manifestations,and ususally found in testicular biopsy.Earlier management promises better prognosis.