高强度超声聚焦热疗序贯FOLFOX-4方案治疗胃癌腹膜后淋巴结转移

目的]观察高强度超声聚焦热疗序贯FOLFOX-4方案治疗胃癌腹膜后淋巴结转移与单纯FOLFOX-4方案治疗的疗效及安全性。方法]85例胃癌腹膜后淋巴结转移患者随机分成两组,即高强度超声聚焦热疗序贯FOLFOX-4方案组（试验组,n=44）和单纯FOLFOX-4方案组（对照组,n=41）,观察两组的治疗疗效和不良反应。结果]最终两组的病例为44例和40例（对照组有1例患者死亡）。试验组的治疗有效率为68.2%,对照组为45.0%,两组差异具有统计学意义（P〈0.05）。两组患者治疗后的疼痛和生活质量得到不同程度的改善,且试验组的改善程度均高于对照组（P〈0.05）。试验组和对照组的不良反应发生率没有明显差异（P〉0.05）。两组1年生存率没有明显差异（P〉0.05）。结论]高强度超声聚焦热疗序贯FOLFOX-4方案化疗治疗胃癌腹膜后淋巴结转移较单纯FOLFOX-4方案更加有效。

High-intensity Focused Ultrasound Followed by FOLFOX-4 Regimen Chemotherapy for Gastric Cancer Patients with Retroperitoneal Lymph Nodes Metastasis

Purpose] To investigate the efficacy and toxicities of high-intensity focused ultrasound（HIFU） followed by FOLFOX-4 regimen chemotherapy and FOLFOX-4 regimen chemotherapy alone in the treatment for gastric cancer patients with retroperitoneal lymph nodes metastasis. Methods] Eighty-five gastric cancer patients with retroperitoneal lymph nodes metastasis were randomly divided into two groups：HIFU followed by FOLFOX-4 regimen group（experimental group,n=44） and FOLFOX-4 regimen alone group（control group,n=41）. The efficacy and toxicities in the two groups were investigated.Results] The final patients of two groups were 44 and 40（one patient died during treatment）. The efficacy of experimental group and control group were 68.2% and 45.0%,respectively,with significant difference（P〉0.05）. After treatment,the pain and quality of life in the two groups were improved,and the increase was significant in experimental group than that in control group（P〉0.05）. There was no difference both in toxicities and 1-year survival between experimental group and control group（P〉0.05）.Conclusion] HIFU followed by FOLFOX-4 regimen chemotherapy in treatment for gastric cancer patients with retroperitoneal lymph nodes metastasis is more effective than FOLFOX-4 regimen chemotherapy alone.