Protective effect of magnolol-loaded polyketal microparticles on lipopolysaccharide-induced acute lung injury in rats |
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| Authors: | Tsuimin Tsai Chun-Liang Chou Lu-Chun Liu Tz-Chong Chou |
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| Affiliation: | 1. Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Taipei, Taiwan;2. Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan;3. Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan;4. Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan |
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| Abstract: | ![]()
Magnolol has shown inhibitory effects on NO production and TNF-alpha production in lipopolysaccharide (LPS)-activated macrophages and LPS-induced acute lung injury; however, the poor solubility of magnolol has hindered its clinical success. In this study, magnolol-loaded microparticles were prepared via single emulsion method from a polyketal polymer, termed PK3. The particle sizes of magnolol-loaded PK3 microparticle is 3.73?±?0.41?μm, and was suitable for phagocytosis by macrophages and pulmonary drug delivery. PK3 microparticles exhibited excellent biocompatibility both in vitro and in vivo. More importantly, intratracheal delivery of these magnolol-loaded microparticles significantly reduced the lung inflammatory responses at low dosage of magnolol (0.5?mg/kg), and have great clinical potential in treating acute lung injury. |
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| Keywords: | Magnolol polyketal microparticles anti-inflammatory. pulmonary drug delivery acute lung injury |
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