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| 乙肝疫苗母婴阻断无(弱)应答影响因素的非条件Logistic回归分析 | |
| 引用本文： | 张文增,史继新,冀国强,马玉欣,张松建. 乙肝疫苗母婴阻断无(弱)应答影响因素的非条件Logistic回归分析[J]. 现代预防医学, 2010, 37(6) |
| 作者姓名： | 张文增 史继新 冀国强 马玉欣 张松建 |
| 作者单位： | 北京顺义区疾病预防控制中心,北京,101300 |
| 摘 要： | [目的]探讨乙肝疫苗母婴阻断无(弱)应答发生的影响因素。[方法]选择北京市顺义区2005~2008年孕期或住院分娩时乙肝病毒表面抗原(HBsAg)检测阳性母亲所生的儿童,分析乙肝疫苗母婴阻断无(弱)应答发生的影响因素,在单因素的基础上进行多因素非条件Logistic回归分析,探索接种乙肝疫苗阻断HBV母婴传播的影响因素。[结果]共调查223名儿童,抗-HBs阳性者185人,阳性率为85.7%,无(弱)应答率为14.3%。非条件Logistic回归分析结果显示,HepB首针及时接种、儿童完成接种年龄、分娩方式及母亲HBV感染状况是影响儿童抗-HBs无弱应答率的主要因素,其发生无(弱)应答的OR值分别为0.264、2.292、2.158和0.370。[结论]乙肝疫苗接种后的无(弱)应答率与文献报道基本一致。HepB首针未及时接种、儿童完成接种年龄较大、顺产及母亲双阳性的儿童乙肝疫苗母婴阻断时容易发生无(弱)应答。 |
| 关 键 词： | 乙肝疫苗 无(弱)应答 影响因素 儿童 |
NON-CONDITION LOGISTIC ANALYSIS ON INFLUENCING FACTORS OF HEPATITIS B VACCINE IN PREVENTING MOTHER-TO-INFANT TRANSMISSION OF HEPATITIS B VIRUS |
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| ZHANG Wen-zeng,SHI Ji-xin,JI Guo-qiang,et al.. NON-CONDITION LOGISTIC ANALYSIS ON INFLUENCING FACTORS OF HEPATITIS B VACCINE IN PREVENTING MOTHER-TO-INFANT TRANSMISSION OF HEPATITIS B VIRUS[J]. Modern Preventive Medicine, 2010, 37(6) | |
| Authors: | ZHANG Wen-zeng SHI Ji-xin JI Guo-qiang et al. |
| Affiliation: | ZHANG Wen-zeng,SHI Ji-xin,JI Guo-qiang,et al. (Shunyi Center for Disease Control , Prevention,Beijing 101300,China) |
| Abstract: | [Objective] To explore the influencing factors of Hepatitis B vaccine (HepB) in preventing mother-to-infant transmission of Hepatitis B virus (HBV). [Methods] The children whose mothers were HBsAg positive during pregnancy or childbearing were selected in Shunyi District of Beijing between 1997 and 2005, the non (low)-responsive rate after HepB immunization was calculated and the influencing factors were determined with simple factor analysis and multi-factors Logistic regression model. [Results] 223 childr... |
| Keywords: | Hepatitis B vaccine Non (low) immune response Influencing factor Children |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |