细菌内毒素对缺氧缺血性脑损伤新生大鼠远期智能的影响

目的：探讨细菌内毒素脂多糖（LPS）对缺氧缺血性脑损伤（HIBD）新生大鼠远期智能的影响，方法，建立新生大鼠LPS＋HIBD模型，于新生大鼠缺氧前4h给予腹腔注射LPS0．3mg/kg,HIBD组和对照组仅给予腹腔注射生理盐水，采用迷宫实验观察远期学习记忆能力的改变。结果：LPS＋HIBD组学习记忆能力明显低于HIBD组，表现在达标所需反映次数明显高于HIBD组（P＜0．05），而正确率支明显低于HIBD组（P＜0．05），结论：LPS对缺氧缺血引起的脑损伤有增敏作用，可进一步降低HIBD后的学习和记忆能力。

The effect of bacterial endotoxin lipopolysaccharide on long-term intelligence of newborn rat with hypoxic-ischemic brain damage

Objective To investigate the effect of bacterial lipopolysaccharide on long term intelligence of the newborn rats with hypoxic ischemic brain damage (HIBD).Methods The models of newborn rats LPS+HIBD were established and 0.3 mg/kg dosage lipopolysaccharide was administered to the 7 day old rats 4 hours before hypoxic ischemia , HIBD group and control group only were administered saline .With maze test ,the changes of long term learning memory abilities in rats were observed.Results The function of learning and memory was lower in LPS+HIBD group than in HIBD group. The times to reach the standard increased significantly in LPS+HIBD group ; the correct rate lessened significantly in LPS+HIBD group. There was significantly difference between HIBD group and control group(P<0.05).Conclusions LPS can sensitize the immature rat brain with hypoxic ischemic brain damage and lower the learning memory ability after HIBD further.