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| 他汀类药物对脓毒症一氧化氮合酶的影响 | |
| 引用本文： | 冼海涛,姚华国,张媛莉. 他汀类药物对脓毒症一氧化氮合酶的影响[J]. 中国热带医学, 2008, 8(3): 487-489 |
| 作者姓名： | 冼海涛 姚华国 张媛莉 |
| 作者单位： | 广东医学院附属医院危重医学科,广东,湛江,524001 |
| 摘 要： | 近年有研究显示，他汀类药物能改善脓毒症动物模型预后，提高生存率，其主要机理是通过抑制诱导型一氧化氮合酶表达（iNOS），促进内皮型一氧化氮合酶（eNOS）表达，恢复iNOS与eNOS平衡，保护内皮功能，现将其归纳作一综述。 |
| 关 键 词： | 他汀类 脓毒症 机制 一氧化氮合酶 |
| 文章编号： | 1009-9727（2008）3-487-03 |
| 收稿时间： | 2007-03-10 |
| 修稿时间： | 2007-03-10 |
Effects of statins on the nitric oxide synthase during sepsis |
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| XIAN Hai-tao,YAO Hua-guo,ZHANG Yuan-li. Effects of statins on the nitric oxide synthase during sepsis[J]. China Tropical Medicine, 2008, 8(3): 487-489 | |
| Authors: | XIAN Hai-tao YAO Hua-guo ZHANG Yuan-li |
| Affiliation: | XIAN Hai - tao, YAO Hua - guo, ZHANG Yuan - li. (Department of Critical Care Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong, P. R. China) |
| Abstract: | Recently animal experiments indicates that statins are available for treatment of sepsis, which can improve animals＇ survival rate. The main mechanisms by which statins appear to be an effective drug for sepsis is increased expression of endothelial nitric oxide synthase（eNOS）, in conjunction with down- regulation of inducible nitric oxide synthase（iNOS）. Combined, this keeps the balance between eNOS and iNOS, thus restoring endothelial funetion. Now relevant experiments are reviewed in this paper. |
| Keywords: | Satins Sepsis Mechanisms Nitric oxide synthase |
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