颅内动脉瘤雌激素受体与血管平滑肌细胞表型蛋白的表达

目的：探讨正常人体动脉血管和颅内动脉瘤的血管平滑肌（VSMC）雌激素受体（ERs）和VSMC表型蛋白的表达变化。方法：采用免疫组化法检测了15例颅内动脉瘤和7例正常对照动脉血管中ERs、α-平滑肌肌动蛋白（α-SMA）和结蛋白（Desmin）的表达。结果：颅内动脉瘤VSMC的ERα和ERβ表达均高于对照动脉血管表达水平,具有显著性差异;颅内动脉瘤VSMC的α-SMA和Desmin表达均低于对照动脉血管表达水平,具有显著性差异。结论：人类颅内动脉瘤VSMC表达ERs水平升高与VSMC表型蛋白表达降低,可能与颅内动脉瘤的形成有关。

The Expression of Estrogen Receptors and Vascular Smooth Muscle Phynotype Protein in Human Intracranial Aneurysms

Objective：To investigate the expression of estrogen receptors （ERs） and phynotype protein on smooth muscle cell（VSMC） of intracranial aneurysmas and normal artery. Methods： The expression of ERs,α-SMA and Desmin in samples from the fifteen cases of Human Intracranial Aneurysms and seven cases of normal control group was examined with the immunohistochemical method. Results ： The value of ERα and ERβ expression in aneurysms more than in normal artery, there are significant statistical differences. The value of α-SMA and Desmin expression in aneurysms less than in normal artery, there are significant statistical differences. Conclusion： the elevated expression of ERs and down-regulation of VSMC phenotype protein in aneurysms, which may correspond to the formation of aneurysms.