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P-selectin glycoprotein ligand-1-mediated leukocyte recruitment regulates hepatocellular damage in acute obstructive cholestasis in mice |
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| Authors: | Stefan Dold Matthias W. Laschke Yilin Zhau Martin Schilling Michael D. Menger Bengt Jeppsson Henrik Thorlacius |
| Affiliation: | 1. Department of Surgery, Malm? University Hospital, Lund University, 205 02, Malm?, Sweden 2. Department of General, Visceral, Vascular, and Pediatric Surgery, University of Saarland, Homburg/Saar, Germany 3. Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany |
| Abstract: | ObjectiveLeukocytes mediate hepatocellular injury in obstructive cholestasis. The aim of the present study was to define the role of P-selectin glycoprotein ligand-1 (PSGL-1) in cholestasis-induced leukocyte recruitment and liver damage. |
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