Cytotoxic steroidal saponins from the rhizomes of Asparagus oligoclonos |
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Authors: | Kim Geum-Soog Kim Hyun-Tae Seong Jae-Duck Oh Sei-Ryang Lee Chong-Ock Bang Jin-Ki Seong Nak-Sul Song Kyung-Sik |
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Institution: | Ginseng & Medicinal Crops Division, National Institute of Crop Science (NICS), Rural Development Administration (RDA), Suwon 441-857, Korea. |
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Abstract: | Two new steroidal saponins, aspaoligonins A (2) and B (3), were isolated from the methanolic extract of the rhizomes of Asparagus oligoclonos together with a known spirostanol saponin, asparanin A (1). Aspaoligonins A and B were characterized as (25S*)-5beta-spirostan-3beta,17alpha-diol 3-O-beta-D-glucopyranosyl (1-->2)-beta-D-glucopyranoside and (25S*)-5beta-spirostan-3beta,17alpha-diol 3-O-alpha-L-rhamnopyanosyl (1-->4)-beta-D-xylopyranosyl-(1-->2)]-beta-D-glucopyranoside, respectively, by spectrometric analyses including HRFABMS and 2D NMR. Compounds 1-3 were cytotoxic against five human tumor cell lines with IC50 values of 2.05-2.84 microg/mL. |
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