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| 异佛尔酮二异氰酸酯免疫毒性的实验研究 | |
| 引用本文： | 段仁勤,章旭杰,陈炎磐,毛福英. 异佛尔酮二异氰酸酯免疫毒性的实验研究[J]. 华中科技大学学报(医学版), 1990, 0(Z1) |
| 作者姓名： | 段仁勤 章旭杰 陈炎磐 毛福英 |
| 作者单位： | 同济医科大学职业医学研究所工业毒理研究室(段仁勤，章旭杰，陈炎磐)，同济医科大学职业医学研究所工业毒理研究室(毛福英) |
| 摘 要： | 本文选用小鼠溶血空斑形成试验研究了异佛尔酮二异氰酸酯(IPDI)对Bal/C小鼠脾细胞的作用,选用ANAE染色法观察了IPDI对SD大鼠外周血T细胞的影响,并采用体外培养方法研究了IPDI对人外周血T细胞在PHA刺激下增殖转化的影响。结果表明,IPDI对小鼠脾脏抗体生成细胞的数量和功能均有抑制作用,并呈现出剂量-反应关系;而对细胞免疫反应在大鼠和人均表现为双向作用。 |
| 关 键 词： | 异佛尔酮二异氰酸醋 免疫性 脾细胞 T-淋巴细胞 |
Experimental Studies on Immunotoxicity of Isophorone Diisocyanate |
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| Duan Renqin,Zhang Xujie,Chen Yanpan,Mao Fuying. Experimental Studies on Immunotoxicity of Isophorone Diisocyanate[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 1990, 0(Z1) | |
| Authors: | Duan Renqin Zhang Xujie Chen Yanpan Mao Fuying |
| Affiliation: | Duan Renqin,Zhang Xujie,Chen Yanpan,Mao FuyingDepartment of Industrial Toxicology,Institute of Occupational Medicine,Tongji Medical University,Wuhan |
| Abstract: | Using hemolysis plaque forming test and quantitated spectrop-hotometrical hemolysis method,we studied the effect of Isophorone Diisocya-nate (IPDI) on the spleen cells in BaI/c mice.IPDI was found to exert an inhibitory effect on the number and function of the antibody-producing cells in the spleen.This effect was dose-related.The effect of IPDI on the cellular immunity in rats was also studied by ANAE staining method.Our experimental results demonstrate that the count and percentage of T lymphocytes increase in the rats injected with 1/50 and 1/25 LD IPDI.However,in the rats injected with 1/10 LD IPDI,the count and percentage of T cells decrease,and the weight of the thymus gland reduces.The in vitro test indicates that IPDI has a dual-directional effect on human T lymphocytes. |
| Keywords: | isophorone diisocyanate immunity spleen cells T lymphocytes |
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