优思明与达英-35治疗多囊卵巢综合征的临床疗效对比

目的:观察屈螺酮炔雌醇(优思明)和炔雌醇环丙孕酮(达英-35)治疗多囊卵巢综合征(PCOS)的临床疗效对比。方法:将62例研究对象随机分成优思明组(30例)和达英-35组(32例),连续治疗3个周期,月经来潮1～5天内复诊,评价治疗前后性激素、脂代谢、体重等临床指标。结果:优思明和达英-35均能降低血清总睾酮(T)、黄体生成素(LH)及改善多毛症状,差异有统计学意义(P<0.05);达英-35组的高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、总胆固醇(T-CHO)治疗后明显增高,差异有统计学意义(P<0.05);优思明组HDL、T-CHO治疗后明显增高,差异有统计学意义(P<0.05);两组治疗前后体重、雄激素、LH水平差值差异没有统计学意义(P>0.05)。结论:优思明和达英-35均能有效改善PCOS高雄激素血症、高LH的内分泌环境及多毛症状,对体重无明显增加。其中优思明对脂代谢的影响小于达英-35,更有利于PCOS患者远期心脑血管疾病的防治。

Comparison of clinical efficacies of Yasmin and Diane-35 in treatment of polycystic ovary syndrome

Objective:To observe and compare the clinical efficacies of Yasmin and Diane-35 in treatment of polycystic ovary syndrome(PCOS).Methods:Sixty-two study objects were randomly divided into Yasmin group(30 cases) and Diane-35 group(32 cases),then all the cases were treated for three courses of treatment,subsequent visit was conducted at 1-5 days during the menstrual cycle,the clinical indexes(sex hormones,lipid metabolism,body weight) before and after treatment were evaluated.Results:Yasmin and Diane-35 both could reduce serum levels of total testosterone and luteinizing hormone(LH) and improve hairy symptom,there was significant difference(P<0.05).In Diane-35 group,the levels of high density lipoprotein(HDL),low density lipoprotein(LDL),and total cholesterol(TC) after treatment were significantly higher than those before treatment(P<0.05).In Yasmin group,the levels of HDL and TC after treatment were significantly higher than those before treatment(P<0.05).There was no significant difference in body weight,androgen level,and LH level before and after treatment in the two groups(P>0.05).Conclusion:Both Yasmin and Diane-35 can effectively improve the endocrine environment of hyperandrogenism and high LH and hairy symptom among the patients with PCOS,which can’t increase body weight.The impact of Yasmin on lipid metabolism is smaller than that of Diane-35,which is more helpful to prevent and treat long-term cardiovascular and cerebrovascular diseases among the patients with PCOS.