尿激酶型纤溶酶原激活物(uPA)及其抑制物-1(PAI-1)在子宫内膜癌中的表达及其临床病理意义

目的:探讨尿激酶型纤溶酶原激活物(uPA)及其抑制物-1(PAI-1)在子宫内膜癌发生、发展中的作用。方法:子宫内膜癌标本61例,同时取患者相应的癌旁正常子宫内膜组织作为对照。应用组织芯片法与免疫组织化学法,检测每例子宫内膜癌标本和正常子宫内膜组织中uPA及其抑制物PAI-1的表达情况。结果:PAI-1在子宫内膜癌组织中的表达率为37.7%(23/61),在正常子宫内膜组织中的表达率为60.7%(37/61),两组间差异有统计学意义(χ2=6.428,P<0.05);PAI-1的表达与患者的年龄、组织类型、肿瘤组织学分级、淋巴结转移无关(均P>0.05),但与临床病理分期有关(P<0.05)。uPA在子宫内膜癌组织中的阳性表达率为42.6%(26/61),在正常子宫内膜组织中的阳性表达率为21.3%(13/61),两组间差异有统计学意义(χ2=6.369,P<0.05);uPA的表达与患者的年龄、组织类型、肿瘤组织学分级无关(均P>0.05),但与肿瘤临床病理分期和肿瘤淋巴结转移有关(P<0.05)。此外,uPA和PAI-1在子宫内膜癌中阳性表达差异无统计学意义(P>0.05)。结论:uPA和PAI-1的异常表达在子宫内膜癌的发生中有重要作用,PAI-1的低表达和uPA的高表达与子宫内膜癌临床病理进展有关。

Expressions of urinary plasminogen activator(uPA) and its inhibitor-1(PAI-1) in endometrial cancer and their clinicopathological significances

Objective: To explore the roles of urinary plasminogen activator(uPA) and its inhibitor-1(PAI-1) in occurrence and development of endometrial cancer. Methods: Sixty-one samples of endometrial cancer were collected from the hospital,at the same time,the samples of normal endometrium tissue adjacent endometrial cancer were obtained as control group.Tissue microarray and immunohistochemical method were used to detect the expression levels of uPA and PAI-1 in endometrial cancer samples and normal endometrium samples. Results: The expression rates of PAI-1 in endometrial cancer samples and normal endometrium samples were 37.7%(23/61) and 60.7%(37/61),respectively,there was statistically significant difference between the two groups(χ2=6.428,P<0.05).There was no correlation between PAI-1 expression and age,histological type,histological grade,and lymph node metastasis(P>0.05),but PAI-1 expression was correlated with clinicopathological stage(P<0.05).The expression rates of uPA in endometrial cancer samples and normal endometrium samples were 42.6%(26/61) and 21.3%(13/61),respectively,there was statistically significant difference between the two groups(χ2=6.369,P<0.05).There was no correlation between uPA expression and age,histological type,and histological grade(P>0.05),but uPA expression was correlated with clinicopathological stage and lymph node metastasis(P<0.05).In addition,there was no statistically significant difference in the positive expression rates of uPA and PAI-1 in endometrial cancer samples. Conclusion: The abnormal expressions of uPA and PAI-1 play important roles in the occurrence of endometrial cancer,the low expression of PAI-1 and high expression of uPA are related to the clinicopathological progression of endometrial cancer.