庚型肝炎病毒感染研究

目的　了解山东省HGV感染状况,探讨HGV感染与HCV或HBV感染的关系。方法　应用酶联免疫吸附试验(ELISA)对1082例病毒性肝炎患者、77例非甲至戊型肝炎患者和361名献血员进行了血清抗-HGV检测。结果　共检出血清抗-HGV阳性者53例,阳性率3.49%。丙型肝炎患者血清抗-HGV阳性率(8.93%)显著高于乙型肝炎患者(3.32%)(χ2=8.80,P<0.01)。慢性肝炎患者血清抗-HGV阳性率(4.82%)显著高于急性肝炎患者(0.79%)(χ2=10.79,P<0.01)。重型肝炎患者血清抗-HGV阳性率(8.00%)显著高于急性肝炎患者(χ2=10.23,P<0.01)。结论　HGV感染可表现为病毒携带状态、亚临床型和不同临床类型,丙型肝炎患者较乙型肝炎患者更易重叠感染HGV,HGV与HCV或HBV重叠感染可能与病情加重和慢性化的形成有关

Study on Hepatitis G Virus infection

OBJECTIVE: To find out the situation of HGV infection in Shandong Province, and to explore the relations between HGV infection and HCV or HBV infection. METHODS: Enzyme linked immunosorbent assay (ELISA) was used to determine the serum anti-HGV in 1,082 patients with viral hepatitis, 77 patients with non A-E hepatitis and 361 blood donors. RESULTS: 53 patients whose serum anti-HGVs were positive (positive rate: 3.49%) were noticed. The anti-HGV positive rate (8.93%) in patients with Hepatitis C was remarkably higher than that (3.32%) in patients with Hepatitis B (chi 2 = 8.80, P < 0.01). The anti-HGV positive rate (4.82%) in patients with chronic hepatitis was significantly higher than that (0.79%) in patients with acute hepatitis (chi 2 = 10.79, P < 0.01). The anti-HGV positive rate (8.00%) in patients with severe hepatitis was obviously higher than that in patients with acute hepatitis (chi 2 = 10.23, P < 0.01). CONCLUSION: The manifestations of HGV infection can be expressed as virus-carriers, subclinical infection or various clinical types. Patients with Hepatitis C were more subjective to be overlapped with HGV than the patients with Hepatitis B; moreover, HCV or HBV infection superinfected with HGV is associated with exacerbation of patients' condition and the formation of chronic infection.