颧部褐青色痣危险因素的病例对照研究

目的　探讨颧部褐青色痣的发病危险因素。方法　对100例患者进行1∶1配对的病例对照研究,通过条件logistic回归多因素和单因素分析筛选主要危险因素。结果　该病患者有较高的家族史暴露率,提示该病有“遗传易感性”存在。环境危险因素有化妆品应用史和紫外线暴露史,但每一因素均不能解释所有病例。结论　认为遗传易感性与环境危险因素的联合作用可以解释颧部褐青色痣的发病过程,遗传基因的定位与环境因素的联合研究对揭示颧部褐青色痣的病因具有重要意义。

A case-control study on the risk factors in naevus fusco-caeruleus zygomaticus

OBJECTIVE: To determine the risk factors of naevus fusco-caeruleus zygomaticus, a case-control study was conducted in 100 cases. METHODS: The selection of major risk factors was through logistic regression and chi 2-test. RESULTS: It was suggested that the high exposed rate in the family history of objectives was related to "genetic susceptibility". Histories of using cosmetics and exposure to ultraviolet ray were identified as environmental risk factors. However, there was no single factor that could completely explain the etiology of naevus fusco-caeruleus zygomaticus. CONCLUSION: We believe that coordinating effects of both susceptibility in genetics and environmental risk factors may play important roles in the pathogenesis of naevus fusco-caeruleus zygomaticus. Thus combined research on the location of gene mutation with environmental factors is important in the discovery of the etiology of naevus fusco-caeruleus zygomaticus.